The comparative production trial was performed at Phytoplant Research authorized facilities in Córdoba (Spain). A cabinet for indoor cultivation of 2 m2 of cultivated area was used. A total of 8 plants for each cultivar (8 plants m-2) were cultivated. The cabinet was equipped with two 600 W m-2 Philips Greenpower 600W 400V EL lights providing a photon flux density of approximately 700 μmol m-2 s-1. Plants were cultivated in 8.5 L pots filled and maintained for 4 weeks in vegetative stage under long day length (18 h light day-1) and then induced to flower under short day length (12 h light day-1) and maintained for an additional 5 weeks, when plants were harvested and data on individual plant height and total fresh weight (FW) were taken. The range adopted for climatic parameters were 25±3°C, 50-70% of relative humidity, and 350-400 ppm of carbon dioxide. Plants were cultivated on a coconut natural growth medium (Coco Professional Plus, Canna Continental, Los Angeles, CA) and nutrient solutions were prepared by using the fertilizers Coco A+B from Canna Continental. The method described by Lichtenthaler (1987) for extracting and quantifying chlorophyll in μg mL-1 was employed to measure chlorophyll in ‘Pilar’ (not mottled green leaves) and in ‘Divina’ (variegated leaves) from 6 samples of each cultivar taken from representative leaves. After the drying stage, data on total dry weight (TDW) were obtained after manual processing, separation and taking the respective data on dry weights of vegetal raw material components: leaves (LDW), inflorescences (FDW), and stalks (SDW). Approximately 5 g of inflorescences and 5 g of leaves were sampled for each one of the 16 plants. Samples were differently prepared, stored and extracted before cannabinoid and terpenoid analysis, depending on the secondary metabolites to be analyzed. For cannabinoid analysis, a Agilent 7890 B gas chromatograph was used. Compounds were detected by mass spectrometry using a MS 5977B from Agilent and for terpenoid analysis, a Agilent 7820 B gas chromatograph was used.